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Smicet
Pantoprazole ( sold under various brand names including Somac, Pantoloc, Protium, Pantecta, Protonix, and Pantoheal ) is a proton pump inhibitor drug that inhibits gastric acid secretion.

Pantoprazole is used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. Initial treatment is generally of eight weeks' duration, after which another eight week course of treatment may be considered if necessary.[citation needed] It can be used as a maintenance therapy for long term use after initial response is obtained.

Pantoprazole is metabolized in the liver by the cytochrome P450 system.Metabolism mainly consists of demethylation by CYP2C19 followed by sulfation. Another metabolic pathway is oxidation by CYP3A4. Pantoprazole metabolites are not thought to have any pharmacological significance. Pantoprazole is relatively free of drug interactions; however, it may alter the absorption of other medications that depend on the amount of acid in the stomach, such as ketoconazole or digoxin. Generally inactive at acidic pH of stomach, thus it is usually given with a pro kinetic drug. Pantoprazole binds irreversibly to H+K+ATPase(Proton pumps) and suppresses the secretion of acid. As it binds irreversibly to the pumps, new pumps have to be made before acid production could be resumed. Half life of the drug is approx 24 hours.

Domperidone
is an antidopaminergic drug, and used orally, rectally or intravenously, generally to suppress nausea and vomiting, or as a prokinetic agent. It has also been used to stimulate lactation in women, and could be used for the purpose of breast enlargement.

There is some evidence that domperidone has antiemetic activity.Domperidone is used, together with metoclopramide, cyclizine, and 5HT3 receptor antagonists (such as granisetron) in the treatment of nausea and vomiting.

Domperidone blocks the action of dopamine. It has strong affinities for the D2 and D3 dopamine receptors which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which, among others, regulates nausea and vomiting (area postrema on the floor of the fourth ventricle and rhomboid fossa).
 

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